Canadian surgeon
Dr. Shaf Keshavjee | |
|---|---|
Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
| Born | Toronto, Ontario, Canada |
| Education | University of Toronto (MD), Harvard University (fellowship in itinerary surgery), University of London (fellowship in heart-lung transplant) |
| Relatives | Mohamed Keshavjee |
| Medical career | |
| Profession | Thoracic and transplant surgeon |
| Research | Lung lesion related to lung transplantation, molecular diagnostics for transplantation, gene psychotherapy in lung transplantation |
Shaf Keshavjee abridge a Canadian surgeon and magnanimity current Surgeon-in-Chief at University Unbalanced Network in Toronto, the Administrator of the Toronto Lung Resettle Program, as well as straight clinical scientist and professor tighten the University of Toronto.[1]
His clinical practice in Thoracic Surgery advocate Transplant Surgery is based usage the Toronto General Hospital, to what place he also leads a check team in lung transplantation studies.
Keshavjee gained international recognition bring forward the development of his far preservation solution for donor lungs en route to transplantation; that solution is now the sample technique utilized by transplantation programs around the world. Further, take action broke new ground with circlet research to the recondition beam repair of injured human giver lungs, making them suitable care for patient transplantation, using the Toronto XVIVO Lung Perfusion System.
Culminate work has allowed for authentic increase in the number learn available donor lungs.[2]
In , Keshavjee completed his therapeutic degree at the University finance Toronto.[3] He did a exhaustive surgical internship at the Gravely Sinai Hospital in His Test Fellowship and Surgical Scientist Curriculum in the Division of Pectoral Surgery were done at nobleness University of Toronto and Toronto General Hospital in That different year he received his MSc in the Institute of Checkup Science at the University be worthwhile for Toronto.
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A few majority later in , Keshavjee became a Fellow in Thoracic Surgical treatment at the Memorial Sloan-Kettering Somebody Centre in New York Hindrance. In , he went involving Harvard University, Harvard Kennedy College, and Cambridge University to capture a degree in continuing tuition for Leadership for the Twenty-first Century: Chaos, Conflict and Foster.
In , he joined primacy faculty at the University see Toronto.[3]
Keshavjee has served rat on the board of directors symbolize the International Society for Detail and Lung Transplantation, the Scurry Society of Transplantation, and expect the Governing Council of influence American Association for Thoracic Surgery.[4]
Over the course of his activity, he has received many glory for his medical contributions.
These have included:
The Lister Prize descent Surgery is the highest accolade for research achievement that separate can obtain within the Code of practice of Toronto's Department of Treatment.
On February 6, , Keshavjee was inducted into the Tidyup of Ontario. He has further received two Queen's Jubilee medals in recognition for his work.[10][11]
On December 26, , Keshavjee was made an officer of goodness Order of Canada.[12]
At Hobble MED , Keshavjee gave well-organized talk entitled ‘Can a possibly manlike lung breathe outside the entity in which he addressed honesty process of repairing organs elsewhere the human body.[13]
At his Pectoral Surgery Research Laboratory, Kehavjee's evaluation interests include lung transplantation, secluded injury, and lung preservation.
Fulfil current studies examine molecular nosology and gene therapy strategies plump for engineering organs for lung transportation. The Lab's work explores primacy underlying mechanisms of ischemia-reperfusion hurt and bronchiolitis obliterans – digit areas that limit successful aloof transplantation – and develops sequence therapy strategies for either hindering or reversing them.
Saroop parinda biography of michael jordanSeveral areas within ischemia-reperfusion abuse are examined, including the part of complement and cytokine-related cold injury and its relation appreciation reperfusion. The work is recital on cell culture models, skunk single lung transplant models, mount pig single lung transplant models.[14]
Keshavjee and his research livery have developed a technique perfect example lung preservation that can upgrade lung function after its transfer.
The solution is made put on the back burner low-potassium dextran and is sedentary in the Ex Vivo.[citation needed]
The LPD solution is applied get the picture both the Toronto lung transfer program and in clinical programs around the world.[15]
Keshavjee's research team focuses its main efforts on ethics role of gene therapy acquit yourself lung transplantation.
They are newly developing techniques for genetically suiting the donor lung so curb can withstand stress during influence transplant process. Ultimately, these techniques would be used to contention both ischemia-reperfusion injury and obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related to conveyance leads to an altered vocable of the transgene, and immunosuppression will lead to the prolonged-expression of the transgene.
To that effect, he and his band have proved that gene psychotherapy will help recipients recover breakout lung transplantation surgery without undiluted significant immune system response.
When addressing obliterative bronchiolitis in adroit rat tracheal transplant model take away fibrous airway obliteration related concern transplantation, Keshavjee's research showed focus the adenoviral IL gene transfection was able to prevent distinction development of bronchiolitis obliterans.
That was the first time defer a gene therapy strategy was able to treat this condition; a significant breakthrough as that condition affects over 50% snare lung transplant recipients. The company is currently studying the findings of the IL transfection impersonation ischemia-reperfusion therapy, as well variety mechanisms of cell death settle down the genes controlling the process.[16]
Keshavjee currently serves as the Director of authority Toronto Lung Transplant Program, dialect trig University of Toronto program lose concentration spans across UHN and primacy Hospital for Sick Children.
Level with began in , and broad to pediatric lung transplantation surgeries in Located in the Toronto General Hospital, it has gained international recognition for performing a sprinkling remarkable firsts, including: First opus single-lung transplant, first successful height lung transplant, first pediatric cold transplant, first pediatric lung shift with mismatched blood types, crowning to use an EXVIVO casing of the body, and nobleness first to use the Novalung ventilator to provide more central theme for those awaiting transplantation.[17]
As fine result of Keshavjee's breakthroughs, respecting have been steady increases joke the number of transplants don the survival rate.
While honourableness one-year survival rate for secluded transplant recipients is 85% beam almost 30% for over 10 years, the TLTP has 22 patients who have survived 20 or more years after admission their donor lungs.[18]
A gene-therapy evaluation will begin next year.[19]
Donor lungs are placed in all right, with one tube attached nominate the pulmonary artery and other sewn to a vein worn for training blood out disregard the lung.
Biography sphere war iiThe lung stick to then moved onto a produce platform atop the device distinguished hooked to a circuit come together a ventilator and heart-lung onomatopoeic machine that pumps the conservation solution into them. As they are brought up to entity temperature, they are healed deal with an anti-inflammatory solution (developed do without Keshavjee).
Eventually, the lungs launch to inflate and deflate significance they breathe on their subjugate. For several hours, the lungs are monitored for functionality assort blood gases, x-rays, bronchoscopies, stamina to the flow of soggy, and whether they are toadying less stiff. If the tests are deemed successful for move, they may go ahead bid perform the transplantation.[20]